Microneedle Drug Delivery CRO/CDMO
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RESEARCH & INTELLECTUAL PROPERTY

Research & Intellectual Property

Scientific publications, patent activity and research-platform foundations supporting CASMN microneedle development.
20+Years of research foundation
50+Scientific publications
70+Patent applications

Scientific Foundation

Publications provide scientific context for CASMN’s microneedle development platform. They do not by themselves establish product approval, clinical performance or commercial readiness.

Research Themes

Drug deliveryDissolving microneedlesSustained releasePeptides and biologicsVaccinesAnalytical and formulation research

Featured Research

  1. Shi, Y.; Zhu, X.; Yu, Y.; Jiao, W.; Chen, C.; Wei, X.; Shi, L.; Ma, Y.; Ma, Y.; Gao, Y.; Xing, M. Dual-drug thermosensitive hydrogel-based microneedles for synchronized transdermal delivery of paeoniflorin and glycyrrhizic acid. Int J Pharm 2025, 685, 126237. DOI: 10.1016/j.ijpharm.2025.126237 · View DOI ↗
  2. Xu, B.; Zhang, S.; Liu, H.; Yang, G.; Zhou, Z.; Gao, Y. Double-layered core-shell microneedle patch integrated with microparticles for long-acting treatment of osteoporosis. J Control Release 2025, 384, 113898. DOI: 10.1016/j.jconrel.2025.113898 · View DOI ↗
  3. Xu, B.; Liu, H.; Yang, G.; Zhang, S.; Zhou, Z.; Gao, Y. Novel double-layered PLGA microparticles-dissolving microneedle (MPs-DMN) system for peptide drugs sustained release by transdermal delivery. Int J Pharm 2025, 670, 125128. DOI: 10.1016/j.ijpharm.2024.125128 · View DOI ↗
  4. Peng, X.; Yan, C.; Fan, N.; Sun, C.; Zhang, S.; Gao, Y. Novel Molecular Weight Gradient Hyaluronate Dissolving Microneedles for Sustained Intralesional Delivery and Photodynamic Activation of Hematoporphyrin in Port-Wine Stain Therapy. Polymers 2025, 17, 1238. DOI: 10.3390/polym17091238 · View DOI ↗
  5. Peng, X.; Ma, Y.; Yan, C.; Wei, X.; Zhang, L.; Jiang, H.; Ma, Y.; Zhang, S.; Xing, M.; Gao, Y. Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment. Pharmaceutics 2024, 16, 1022. DOI: 10.3390/pharmaceutics16081022 · View DOI ↗
  6. Ou, J.; Xing, M.; Lu, G.; Wan, C.; Li, K.; Jiang, W.; Qian, W.; Liu, Y.; Xu, R.; Cheng, A.; Zhu, M.; Ju, X.; Gao, Y.; Tian, Y.; Niu, Z. Transcutaneous Immunization of 1D Rod-Like Tobacco-Mosaic-Virus-Based Peptide Vaccine via Tip-Loaded Dissolving Microneedles. Nano Lett 2024, 24, 13118-13125. DOI: 10.1021/acs.nanolett.4c01900 · View DOI ↗
All Publications
  1. Xing, M.; Yang, G.; Liu, H.; Zhou, Z.; Zhang, S.; Gao, Y. Industrializable approach for preparing hydrogel microneedles and their application in melanoma treatment. Int J Pharm 2024, 653, 123883. DOI: 10.1016/j.ijpharm.2024.123883 · View DOI ↗
  2. Cheng, A.; Zhang, S.; Meng, F.; Xing, M.; Liu, H.; Yang, G.; Gao, Y. Nanosuspension-Loaded Dissolving Microneedle Patches for Enhanced Transdermal Delivery of a Highly Lipophilic Cannabidiol. Int J Nanomedicine 2024, 19, 4061-4079.
  3. Xing, M.; Ma, Y.; Wei, X.; Chen, C.; Peng, X.; Ma, Y.; Liang, B.; Gao, Y.; Wu, J. Preparation and Evaluation of Auxiliary Permeable Microneedle Patch Composed of Polyvinyl Alcohol and Eudragit NM30D Aqueous Dispersion. Pharmaceutics 2023, 15, 2007.
  4. Duan, X.; Ma, J.; Ning, M.; Gao, Y. Dissolving Microneedles Loaded with Gestodene: Fabrication and Characterization In Vitro and In Vivo. Iran J Pharm Res 2023, 22, e131819.
  5. Yan, C.; Xing, M.; Zhang, S.; Gao, Y. Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders. Polymers 2023, 15, 3296.
  6. Wang, B.; Zhang, S.; Cheng, A.; Yan, J.; Gao, Y. Soluble Polymer Microneedles Loaded with Interferon Alpha 1b for Treatment of Hyperplastic Scar. Polymers 2023, 15, 2621.
  7. Wang, B.; Liu, H.; Zhang, S. et al. Aspirin microcrystals deposited on high-density microneedle tips for the preparation of soluble polymer microneedles. Drug Deliv Transl Res 2023.
  8. Liu, H.; Wang, B.; Xing, M.; et al. Thermal stability of exenatide encapsulated in stratified dissolving microneedles during storage. Int J Pharm 2023, 636, 122863.
  9. Wang, B.; Zhang, S.; Yang, G.; Zhou, Z.; Xing, M.; Liu, H.; Cheng, A.; Gao, Y. Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation. Asian J Pharm Sci 2023, 18, 100776.
  10. Xing, M.; Liu, H.; Meng, F.; Ma, Y.; Zhang, S.; Gao, Y. Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas. Polymers 2022, 14, 4475.
  11. Xing, M.; Zhang, S.; Ma, Y.; Chen, Y.; Yang, G.; Zhou, Z.; Gao, Y. Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy. J Drug Deliv Sci Technol 2022, 75, 103667.
  12. Liu, H.; Zhang, S.; Zhou, Z.; Xing, M.; Gao, Y. Two-Layer Sustained-Release Microneedles Encapsulating Exenatide for Type 2 Diabetes Treatment. Pharmaceutics 2022, 14, 1255. DOI: 10.3390/pharmaceutics14061255 · View DOI ↗
  13. Zhou, Z.; Xing, M.; Zhang, S.; Yang, G.; Gao, Y. Process optimization of Ca2+ cross-linked alginate-based swellable microneedles for enhanced transdermal permeability. Int J Pharm 2022, 168, 121669.
  14. Zhou, Z.; Zhang, S.; Yang, G.; Gao, Y. Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles. Asian J Pharm Sci 2021, 16, 612-622. DOI: 10.1016/j.ajps.2021.05.002 · View DOI ↗
  15. Wang, B.; Zhang, S.; Zhao, X.; Lian, J.; Gao, Y. Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles. Drug Deliv Transl Res 2021, 12, 944-956.
  16. Xing, M.; Yang, Y.; Zhang, S.; Gao, Y. Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. Eur J Pharm Sci 2021, 165, 105935.
  17. Xing, M.; Wang, X.; Zhao, L.; Zhou, Z.; Liu, H.; Wang, B.; Cheng, A.; Zhang, S.; Gao, Y. Novel dissolving microneedles preparation for synergistic melasma therapy. Int J Pharm 2021, 600, 120406. DOI: 10.1016/j.ijpharm.2021.120406 · View DOI ↗
  18. Cheng, A.; Sun, W.; Xing, M.; Zhang, S.; Gao, Y. The hygroscopicity of polymer microneedles on the performance of dissolving behavior for transdermal delivery. Int J Polym Mater Polym Biomater 2020, 1-7.
  19. He, M.; Yang, G.; Zhao, X.; Zhang, S.; Gao, Y. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release. J Pharm Sci 2020, 109, 1958-1966.
  20. Zhao, X.; Zhang, S.; Yang, G.; Zhou, Z.; Gao, Y. Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles. Polymers 2020, 12.
  21. Chen, Z.; Han, B.; Liao, L.; Hu, X.; Hu, Q.; Gao, Y.; Qiu, Y. Enhanced transdermal delivery of polydatin via inclusion complexes and dissolving microneedles for acute gout arthritis. J Drug Deliv Sci Technol 2020, 55, 101487.
  22. 王雪, 赵小峪, 周泽荃, 邢梦真, 高云华, 赵立春, 张锁慧. 氨甲环酸在治疗黄褐斑领域中的应用进展. 药学研究 2020, 348-354.
  23. 徐可, 杨国忠, 黄蓉, 曹泽明, 田丁阳, 陈云梦, 徐楠, 朱庆文, 高云华. 基于微机电系统技术的新型微针耳穴贴压治疗失眠疗效观察. 辽宁中医杂志 2020, 47, 173-175+224.
  24. Liu, S.; Zhang, S.; Duan, Y.; Niu, Y.; Gu, H.; Zhao, Z.; et al. Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle. Vaccine 2019, 37, 3810-3819.
  25. He, M.; Yang, G.; Zhang, S.; Zhao, X.; Gao, Y. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery. J Pharm Sci 2018, 107, 1037-1045.
  26. Yang, G.; He, M.; Zhang, S.; Wu, M.; Gao, Y. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron. Drug Dev Ind Pharm 2018, 44, 808-816.
  27. 段雪艳, 马佳男, 宁美英, 高云华. 孕二烯酮缓释避孕微针含量及其有关物质的测定方法研究. 中国计划生育学杂志 2018, 26, 15-18.
  28. 刘思齐, 杨国忠, 李明辉, 段跃强, 牛燕, 王希良, 杨英, 高云华, 杨鹏辉. 重组金黄色葡萄球菌肠毒素B蛋白可溶性微针制备及免疫效果研究. 免疫学杂志 2018.
  29. 宋思雨, 李中梁, 高云华, 余俊杰, 南楠, 王瑄, 袁春晓, 王向朝. 用于微针经皮给药成像的扫频OCT系统. 中国激光 2018, 45, 209-216.
  30. 李明辉, 王希良, 邱玉琴, 杨国忠, 刘思齐, 邢丽, 张良艳, 周娅, 杨鹏辉, 高云华. 流感病毒灭活疫苗可溶性微针制备及评价. 免疫学杂志 2017, 33, 477-481, 487.
  31. Chen, J.; Qiu, Y.; Zhang, S.; Gao, Y. Dissolving microneedle-based intradermal delivery of interferon-α-2b. Drug Dev Ind Pharm 2016, 42, 890-896.
  32. Qiu, Y.; Guo, L.; Zhang, S.; Xu, B.; Gao, Y.; et al. DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays. Drug Delivery 2016, 23, 2391-2398.
  33. Qiu, Y.; Li, C.; Zhang, S.; Yang, G.; He, M.; Gao, Y. Systemic delivery of artemether by dissolving microneedles. Int J Pharm 2016, 508, 1-9.
  34. 邱玉琴, 李春, 张锁慧, 杨国忠, 贺美琳, 高云华. 蒿甲醚可溶解微针透皮贴片的制备和评价. 今日药学 2016, 532-537.
  35. 邱玉琴, 薛建强, 高云华. 中国微针技术相关专利综述与分析. 今日药学 2016, 26, 672-675.
  36. Qiu, Y.; Guo, L.; Mao, P.; Gao, Y. Dissolving Microneedle Arrays for Intradermal Immunization of Hepatitis B Virus DNA Vaccine. Procedia Vaccinology 2015, 9, 24-30.
  37. Chen, J.; Qiu, Y.; Zhang, S.; Yang, G.; Gao, Y. Controllable coating of microneedles for transdermal drug delivery. Drug Dev Ind Pharm 2015, 41, 415-422.
  38. 张锁慧, 邱玉琴, 杨国忠, 高云华. 明胶作为左旋肉碱贴膏剂载体的体外经皮渗透性评价. 明胶科学与技术 2014, 34, 181-186.
  39. Qiu, Y.; Gao, Y.; Zhang, S.; Guo, L.; Chen, J.; Xu, B. Immunological effects of microneedle-mediated insulin delivery: Preliminary rat studies. Int J Pharm 2013, 444, 103-105.
  40. Chen, J.; Lei, G.; Qiu, Y.; Zhang, S.; Gao, Y. Fabrication of biodegradable polymer microneedles for transdermal drug delivery applications. Nanotechnology and Precision Engineering 2013, 11, 402-409.
  41. Guo, L.; Chen, J.; Qiu, Y.; Zhang, S.; Xu, B.; Gao, Y. Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant. Int J Pharm 2013, 447, 22-30.
  42. 陈健敏, 郭雷, 邱玉琴, 张锁慧, 高云华. 可生物降解高分子微针的制作及透皮应用. 纳米技术与精密工程 2013, 11, 402-409.
  43. 张锁慧, 邱玉琴, 高云华. 微针辅助左旋肉碱水凝胶制剂体内外经皮渗透性评价. 中国新药杂志 2013, 2309-2313.
  44. Qin, G.; Gao, Y.; Wu, Y.; Zhang, S.; Qiu, Y.; Li, F.; Xu, B. Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomedicine 2012, 8, 221-227.
  45. Zhang, S.; Qin, G.; Wu, Y.; Gao, Y.; Qiu, Y.; Li, F.; Xu, B. Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats. Pharm Res 2011, 28, 117-123.
  46. Wu, Y.; Gao, Y.; Qin, G.; Zhang, S.; Qiu, Y.; Li, F.; Xu, B. Sustained release of insulin through skin by intradermal microdelivery system. Biomed Microdevices 2010, 12, 665-671.
  47. Qiu, Y.; Gao, Y.; Hu, K.; Li, F. Enhancement of skin permeation of docetaxel combining microneedle and elastic liposomes. J Control Release 2008, 129, 144-150.
  48. Wu, Y.; Qiu, Y.; Zhang, S.; Qin, G.; Gao, Y. Microneedle-based drug delivery: delivery parameters and biocompatibility. Biomed Microdevices 2008, 10, 601-610.
  49. 李晓光, 赵荣生, 秦泽莲, 高云华, 张洁, 翟所迪, 徐百. 无痛微针透皮贴片对局部应用利多卡因的促渗作用. 中国新药杂志 2008, 17, 597-601.
  50. Xie, Y.; Xu, B.; Gao, Y. Controlled transdermal delivery of model drug compounds by MEMS microneedle array. Nanomedicine 2005, 1, 184-190.
  51. Li, C.; Wang, Y.; Gao, Y.; Guo, X.Y.; Gu, Z. Magnetically actuated micromixing on an array-pattern microfluidic chip for immunoassay of human thyrotropin. J Nanosci Nanotechnol 2005, 5, 1297-1300.
  52. 赵红, 高云华. 微针——开启透皮给药的又一扇门. 中国医药报 2006, p.007.
  53. 高云华. 微针透皮给药系统研究进展. 中医外治杂志 2005, 14, 3-7.

Intellectual Property Overview

Patent activity relates to microneedle structures, formulations, manufacturing processes and delivery applications. Representative patent certificates are maintained separately to avoid duplicating the qualifications archive.

View Patent Certificates →
Technical Review — Reviewed by: CASMN R&D Team · Last reviewed: August 2026