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3大类6种微针技术

CASMN微针技术平台

微针药物递送是一种主动皮肤渗透增强技术，以微创方式突破角质层并形成微米级通道，融合注射给药和透皮给药优势。

首页›CASMN微针技术平台

微针贴剂技术——创新制剂研发平台技术

微针药物递送作为新型经皮递送技术，是一种主动皮肤渗透增强技术。微针呈针状结构，长度通常为几百微米，作用于皮肤后，可突破皮肤角质层屏障，仅以微创方式穿透表皮，在皮肤表面形成微米级微孔，进而增强药物传递效率；且不会损伤真皮层神经元，能最大限度减少透皮给药相关的疼痛，显著改善皮肤渗透性、提升透皮给药效果。

这一特性可有效克服传统注射给患者带来的不适感、针头恐惧感及相关副作用，同时兼具无痛无创、给药便捷的优势，大幅提高患者的用药依从性。随着微针制备技术持续提升，其发展更助力实现温度敏感型药物的脱冷链运输及储存，显著降低物流成本。

微针药物递送技术融合了注射给药和透皮给药的双重优势，可拓展蛋白、多肽、疫苗、DNA以及强亲水性和强疏水性药物的经皮递送。

01

微针贴剂技术——创新制剂研发平台

微针长度通常为几百微米，可穿透表皮而不损伤真皮层神经元，减少疼痛并改善患者依从性；同时可拓展蛋白、多肽、疫苗、DNA以及强亲水或强疏水药物的经皮递送，并有助于温度敏感型药物脱冷链运输与储存。

微针贴剂技术创新制剂研发平台的多种微针阵列显微图
中科微针微针贴剂技术与多类型微针阵列
02

包衣微针技术

在不溶于水的微针针尖表面包衣药物，扎入皮内后快速释放，适用于微量、精准定量给药。

包衣微针进入皮肤并释放药物的技术原理图
03

溶解微针技术

以水溶性药用高分子辅料为基质，将药物或活性成分均匀分散于基质或针尖，针尖入皮后快速溶解并释放药物。

溶解微针进入皮肤后溶解释药的技术原理图
04

溶胀微针技术

微针贴片不溶于水，针尖入皮后形成溶胀凝胶通道，药物沿通道进入体内；释药后针尖可完整移出，适用于大剂量透皮给药。

溶胀微针形成凝胶通道并释放药物的技术原理图
05

团队成果

团队持续在控释微针、多肽药物、天然产物、光动力治疗等方向发表研究成果，已形成从微针结构设计、处方工艺到药效评价的科研积累。

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